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KMID : 0363120090220030206
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Korean Journal of Pain
2009 Volume.22 No. 3 p.206 ~ p.209
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Antinociceptive Effects of the Essential Oil of Ocimum Basilicum in Mice
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Min Sun-Seek
Han Seung-Ho
Lee Jae-Yong
Kim Chan
Seol Geun-Hee
Im Jae-Hyeung
Kim Hyung-Tae
Lee Kyu-Chang
Kim Hye-Young
Lee Myeong-Jong
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Abstract
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Background: The essential oil of Ocimum basilicum (EOOB) has a pleasant aroma and is known to have antimicrobial and insecticidal activities. In addition, it is used as a pain reliever in folk medicine. However, there are few reports on the antinociceptive activities of EOOB.
Methods: This study examined the antinociceptive effects of EOOB using formalin and a plantar test in mice. In the formalin test, EOOB (50 mg/kg, 100 mg/kg, 150 mg/kg) was administered intraperitoneally and the licking time of the mice was measured. In the plantar test, intraperitoneal EOOB (50 mg/kg, 100 mg/kg) was administered and the withdrawal latency was measured using the Hargreaves method.
Results: In the formalin test, EOOB (50 mg/kg, IP) showed significant decreases in licking time in the second phase. On the other hand, in the plantar test, there were no significant effects in any of the groups examined.
Conclusions: These results support the traditional use of EOOB for the treatment of painful conditions. However, there is a need for more research to determine the active chemical constituents and the precise mechanism.
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KEYWORD
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antinociception, essential oil of ocimum basilicum, formalin test, plantar test
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